Methods and supplements that increase success in IVF treatment: Separating Fact from Fiction - Dr. Senai Aksoy

Methods and supplements that increase success in IVF treatment: Separating Fact from Fiction

Remember!: Literature is full of promising treatment options that disappointed when put under scrutiny in well-designed clinical trials.

Embarking on the journey of IVF treatments can be overwhelming, especially with the myriad of available methods and supplements. It’s essential to approach these methods with caution. Many of them are based on anecdotal evidence or preliminary research. IVF patients should always consult with their fertility specialists before trying any new treatment or supplement.

Chapter 1: Immunotherapy and IVIg

Intravenous immunoglobulin (IVIg) has been suggested as a potential treatment to prevent recurrent miscarriages. However, the verdict is still out regarding its definitive effectiveness in enhancing IVF outcomes.

Chapter 2: Endometrial Tests and Treatments

The ERA Test, designed to determine the optimal day for embryo transfer, and endometrial scratching, believed to aid embryo implantation, have both garnered attention. While some studies vouch for their effectiveness, the consensus remains divided.

Chapter 3: Supplements for Egg Quality

From DHEA to Coenzyme Q10, several supplements have been touted to improve egg quality. Yet, comprehensive studies confirming their effectiveness are still pending.

Chapter 4: Assisting the Embryo

Laser-assisted hatching and time-lapse imaging stand out as innovative approaches in the realm of IVF. The former is tailored to enhance embryo implantation, while the latter offers an uninterrupted view of embryo development. Yet, the jury is still out on their routine applications in the IVF process.

Meanwhile, the potential of Platelet-rich Plasma (PRP) is garnering attention. Sourced directly from a patient’s blood, PRP is enriched with platelets. Within IVF, it’s seen as a promising avenue to revitalize the ovaries and bolster the endometrial lining, particularly for those grappling with recurrent implantation challenges or a thin endometrial layer. The underlying belief is that the growth factors within PRP can trigger tissue repair and rejuvenation. While certain clinics champion its benefits, it’s crucial to note that the supporting evidence is in its early stages. Rigorous clinical trials and expansive studies are pivotal to ascertain its true effectiveness and safety.

Chapter 5: Hormonal and Antioxidant Supplements

Testosterone patches, N-Acetylcysteine (NAC), and Glutathione are among treatments believed to boost IVF outcomes. But, like many other methods, large-scale studies are essential to confirm their efficacy.

Frequently Asked Questions:

  • Is the ERA Test a guarantee for IVF success?
    While the ERA Test can provide insights, it doesn’t guarantee success. Its routine use is a topic of ongoing debate.
  • Can supplements replace conventional IVF treatments?
    No, supplements should be considered complementary. Always consult with a specialist before adding any to your regimen.
  • What is the most promising new IVF technique?
    There’s no one-size-fits-all answer. Different methods work for different patients, and ongoing research continues to bring new options to the forefront.
  • Are all these methods safe?
    Most are considered safe, but like all treatments, they may have side effects. Always discuss potential risks with your fertility specialist.
  • How do supplements like DHEA and Coenzyme Q10 aid in IVF treatments?
    DHEA (Dehydroepiandrosterone) and Coenzyme Q10 are believed to enhance egg quality. While some preliminary research suggests potential benefits, particularly in older women or those with diminished ovarian reserve, large-scale confirmatory studies are still needed.
  • Are techniques like laser-assisted hatching and time-lapse imaging commonly used in IVF clinics?
    These techniques are available in many IVF clinics, but their routine use varies. Some clinics may adopt them based on individual patient needs, while others might be more conservative until more extensive evidence supports their widespread application.
  • How does endometrial scratching supposedly help in IVF?
    The theory behind endometrial scratching is that causing a minor injury to the endometrium (lining of the uterus) might stimulate a healing response, potentially making it more receptive to an implanting embryo. However, more extensive studies are needed to confirm its consistent benefits.
  • Can acupuncture genuinely boost IVF success rates?
    Acupuncture’s role in IVF remains a topic of debate. Some studies suggest potential benefits, especially in reducing stress or improving blood flow to the ovaries and uterus. However, other research shows no significant difference in IVF outcomes with acupuncture.
  • What’s the rationale behind using testosterone patches in IVF treatments?
    Testosterone is believed to enhance the ovarian response to stimulation, especially in women with diminished ovarian reserve. Some smaller studies have shown promise, but as with many treatments on this list, more extensive research is required to establish its routine use.
  • Are there any natural or mild IVF protocols?
    Yes, natural and mild IVF are alternative IVF protocols that use fewer drugs or no drugs at all. The idea is to retrieve fewer but higher quality eggs. Their effectiveness compared to conventional IVF is still being researched.


As we delve deeper into the world of IVF treatments, it’s paramount to remember the importance of evidence-based approaches. While the allure of novel methods can be tempting, it’s essential to approach these methods with caution. Always prioritize discussions with your fertility specialist, ensuring that any treatment or supplement you consider has a strong foundation in scientific research. Remember: Literature is full of promising treatment options that disappointed when put under scrutiny in well-designed clinical trials.


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